|
KMID : 1140120120170020110
|
|
Cancer Prevention Research
2012 Volume.17 No. 2 p.110 ~ p.115
|
|
|
Effects of Samultang on Blood Components, Coagulation and Platelet Aggregation in Rats
|
|
|
|
|
Abstract
|
|
|
|
One traditionally well-known mixed herbal medicine, called Samultang (SM), is believed to help make and protect blood. The effects of the oral administration of SM on systemic hematological change and capabilities of blood coagulation and platelet aggregation in healthy rats have been investigated. A 5-day oral administration of SM increased the red blood cell (RBC) and hemoglobin levels but the mean concentration volume (MCV) of single red blood cell was rather decreased, thus the stimulation of neo differentiation and production of RBC from hematopoietic stem cells by SM might be suggested. Those proportions of lymphocyte, monocyte, and granulocyte were not altered by SM but the total leukocyte counts were decreased. While SM increased the platelet counts, the mean volume of single platelets was not changed so the Dncreased platelet counts might be due to the extended lifespan rather than stimulation of platelet neo production and differentiation. The SM administered-group exhibited increased coagulation time in the extrinsic pathway (prothrombin time, PT) but decreased the time in intrinsic pathway (activated partial thromboplastin time, APTT), suggesting that SM has a slowdown effect on blood coagulation and might be helpful to prevent thrombogenesis in blood vessels. Moreover, the administration of SM also reduced both capability and time of platelet aggregation and thus a 5-day oral administration of SM may have useful effects, including hemopoiesis, thrombopoiesis, antiinflammation, antiplatelet, and hemostasis.
|
|
|
KEYWORD
|
|
|
Samultang (SM), Red blood cell (RBC), Prothrombin time (PT), Activated partial thromboplastin time (APTT), Platelet aggregation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|